Product Details
| Product Name |
Tianeptine sodium salt |
| CAS |
30123-17-2 |
| Appearance |
Off-white powder,very hygroscopic |
| Assay |
99.9% |
| MF | C21H24ClN2NaO4S |
| MW | 458.93 |
Tianeptine sodium salt is a salt of Tianeptine. Tianeptine, a tricyclic compound, is a selective facilitator of 5-HT (serotonin; sc-201146) uptake in vitro and in vivo. Additionally, Tianeptine is reported to act as a selective inhibitor of dopamine uptake . Tianeptine does not have a noted effect on monoamine uptake. In a study utilizing purified synaptosomes from rat brain, Tianeptine was reported to enhance serotonin uptake in selective brain regions. Purified synaptosomes were obtained from rats and incubated with tritium-labeled 5-HT and Tianeptine in vitro . The synaptosomes were then analyzed for uptake and release of 5-HT via a liquid scintillation.
Certificate of Analysis
| Items | Standard | Results |
| Assay by HPLC: | 98% | 99.37% |
| Appearance: | White fine powder | Complies |
| Odor & taste: | Slight bitter | Complies |
| Mesh size: | 100% pass 80mesh | Complies |
| Solubility: | Soluble in water | Complies |
| Loss on drying: | ≤2.0% | 1.15% |
| Heavy metals PPM: | <30ppm | Complies |
|
Microbiology: Total Plate Count: Yeast & Mold: E.Coli: S. Aureus: Salmonella: |
<1000cfu/g <100cfu/g Negative Negative Negative |
800cfu/g 90cfu/g Complies Complies Complies |
| Conclusion: | Conform with USP35 standard | |
Tianeptine is a drug used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. Chemically it is a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.
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