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Product Details
Chinese alias: Chuanpi Ting, Tangerine
English name: Nobiletin
English alias: Naringenine-7-rhamnosidoglucoside
Specification: 40%-98%
CAS Number: 478-01-3
Molecular formula: C21H22O8
Molecular weight: 402.39
Detection method: HPLC
Product Description:
Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue
bulbectomy-induced memory impairment.
Nobiletin was found to have anti-inflammatory and anti-tumor invasion, proliferation, and metastasis in vitro and in animal studies.Nobiletin was also found to potentially inhibit cartilage degradation.
Nobiletin was shown to augment AMPA receptor activity and long-term potentiation in cell culture. Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis have been described.
Nobiletin seems to be a very noble phytochemical with many potential health benefits. The most studied properties of nobiletin are its anti-inflammatory and anti-cancer activities. Nobiletin also helps to lower cholesterol levels and some studies indicate that it may improve impaired memory loss and treat acne.
Anti-inflammatory
Numerous in-vivo and in-vitro studies have demonstrated the anti-inflammatory activity of nobiletin and its metabolites. Nobiletin acts directly as an antioxidant but also interferes with biological inflammatory processes. It inhibits the expression of genes involved in inflammation by blocking the binding of NF-kappaB with DNA. One study showed that nobiletin reduced airway inflammation of asthmatic rats. Treatment of skin cells with nobiletin also reduced inflammation caused by ultraviolet-B radiation.
Anti-cancer
The anti-cancer properties of nobiletin are supported by many scientific studies. Nobiletin act by its antiproliferation effect without being toxic to normal cells. Favourable results have been obtained on cancer cell lines of the liver, stomach, prostate and colon.
Cholesterol Lowering
A study with cultured macrophages demonstrated the cholesterol lowering and atherosclerosis inhibiting properties of nobiletin. Nobiletin also inhibits the formation of macrophage foam cells, macrophages loaded wit lipids, which build up on artery walls.
Memory Loss
One study on a mice model showed that nobiletin my help to improve memory loss. The brains of the mice were chirurgically altered to obtain models of Alzheimer disease. It is not known if nobiletin improves the condition of human Alzheimer patients.
Acne treatment
According to the studies, nobiletin inhibited sebum production on hamsters and inhibited the proliferation of sebocytes, the cells that form the sebaceous gland. This observation led the researchers to conclude that nobiletin could be used as a drug for acne treatment.
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