Factory Supply Bulk High Quality Vonoprazan fumarat CAS:1260141-27-2

  • CasNo1260141-27-2
  • Molecular FormulaC21H20FN3O6S
  • Purity99.5%
  • AppearanceWhite Powder
Inquiry

Product Details

Quick Details

  • CasNo: 1260141-27-2
  • Molecular Formula: C21H20FN3O6S
  • Appearance: White Powder
  • Delivery Time: 3days after we receive the payment
  • Throughput: 1000|Kilogram|Month
  • Purity: 99.5%

Factory Supply Bulk High Quality Vonoprazan fumarat CAS:1260141-27-2

Product Name:Vonoprazan fumarat

CAS:1260141-27-2

F.M.: C21H20FN3O6S

 

Vonoprazan fumarate is a pyrole derivative and potassium-competitive acid blocker (P-CAB) that competitively blocks the potassium-binding site of gastric H (+),K (+)-ATPase, a key enzyme in the process of gastric acid secretion.

 

Vonoprazan is a selective, reversible, and potassium-competitive proton pump inhibitor that inhibits gastric H + /K + ATPase (IC 50 = 17 nM) but does not inhibit porcine Na + /K + ATPase activity when used at a concentration of 10 µM. 1, 2 It maintains its inhibitory effect in both weakly acidic (pH 6.5) and neutral (pH 7.5) conditions with IC 50 values of 19 and 28 nM, respectively.

What is Vonoprazan fumarat

Vonoprazan fumarate is a first-in-class potassium competitive acid blocker. 

It was approved in the Japanese market in February,2015. Vonoprazan can be used for the treatment of gastroduodenal ulcer, reflux esophagitis, and for some drug induced peptic ulcers. 

It can be combined with other antibiotics for the eradication of Helicobacter pylori.

 

Certificate of Analysis

appearance

white or off white crystal powder

complies

solubility

very soluble in methanol and ethanol.

complies

identification

absorbance

nmt0.02 at 420nm(1/20 in methanol)

complies

water

nmt 2.00%

1.02%

residue on ignition

nmt 0.1%

0.05%

heavy metals

nmt 0.001%

complies

total impurities

nmt 0.3%

0.28%

assay

nlt 98.0% and nmt 102.0%

99.00%

(hplc)

calculated on the anhydrous basis

 

residual solvents by gc

hexanes

nmt 0.029%

0.01%

ethylacetate

nmt 0.50%

0.13%

methylenechloride

nmt 0.06%

0.00%

xylene(mixture)

nmt 0.216%

0.01%

Vonoprazan has been used in trials studying the treatment of Erosive Esophagitis.

 

Our Services